|WPC 2016 12 Hot Topics|
The following abstracts have been selected for Hot Topics presentations. Authors of these selected abstracts will present to the broader audience each morning, just before the opening plenary session.
Wednesday, September 21
Hot Topics Panel (8-9AM)
Influenza vaccine or Oseltamivir (Tamiflu®) can protect against microglial activation and a subsequent increase in oxidative stress susceptibility of dopaminergic neurons in the substantia nigra following infection with the non-neurotropic H1N1 influenza virus.
Neuroinflammation In Prediagnostic Parkinson Disease: A Multitracer PET Study of Idiopathic REM Sleep Behaviour Disorder Patients
Moving Through Glass: Exploring augmented reality technology for people with Parkinson's
Neuroprotective potential of transcription factors Lmx1a and Lmx1b in mouse models of Parkinson's disease
Thursday, September 22
Hot Topics Panel (8-9AM)
Large-scale Exploratory Analysis of Genetic Risk Factors for Cognitive Impairment in Parkinson’s Disease
Investigation of exercise vs. repetitive transcranial magnetic stimulation induced dopamine release: [11C]Raclopride PET study
Diffuse Brain Injury in Swine causes Plasmalemmal Dysruption and α-Synuclein Over-expression in the Substantia Nigra
Can Living Micro-Tissue Engineered Axonal Tracts Reconstruct the Nigrostriatal Pathway in PD?
Friday, September 23
Hot Topics Panel (8-9AM)
Understanding the Pathogenesis of Parkinson's Disease Through Genetic Modifiers
Exosome-associated oligomeric alpha-synuclein transmission in vitro
Inhibition of glucosylceramide synthase alleviates aberrations in synucleinopathy models: Link to GBA-related Parkinson's disease
How are we going to tell the children? An overview and review of the Children's literature about Parkinson's disease.
About the Presenters
Marie Davis, MD, PhD
Marion Delenclos, PhD
Instructor, Neuroscience, Mayo Clinic in Jacksonville, Fla.
Dr. Marion Delenclos is an instructor in neuroscience at the Mayo Clinic in Jacksonville, Florida. She obtained her BSc and MSc degree in physiology and cellular biology at Strasbourg University (France) before relocating to Denmark to pursue her graduate studies. During her PhD at Aarhus University, her research focused on characterizing non-motor features and especially depression in animal models of Parkinson’s disease (PD) in collaboration with the laboratory of Marina Romero-Ramos. Delenclos’ strong interest in pre-clinical models of PD led her to join the laboratory of Pamela McLean at the Mayo Clinic in 2012 as a post-doctoral fellow. Her main focus is to investigate in vivo the role of alpha-synuclein oligomers in Parkinson’s disease pathogenesis. She recently developed a new rodent model with the unique ability to rapidly track alpha-synuclein oligomers using a bioluminescent protein complementation strategy. In parallel, she uses state-of-the-art cell-based assays to better understand the transfer of alpha-synuclein between cells, an important mechanism involved in the disease propagation.
Post Doctoral Fellow, Laval University, Quebec, Canada
Hélène Doucet-Beaupré has focused her research as a postdoctoral fellow over the last four years in integrative neurosciences, which directed her toward the understanding of the neurodegenerative mechanisms associated with the development of Parkinson's disease.
Trained as an evolutionary biologist, Doucet-Beaupré studied the mechanism and process underlying mitochondrial evolution to understand its adaptation from the molecular level to the level of whole organism function. Always trying to unravel the mechanisms behind the observations, Doucet-Beaupré says that her best ideas are born in this space.
Although still early in her academic career, Doucet-Beaupré has already received several prestigious scholarships and fellowships awarded to Canada's elite students. Looking to the future, Doucet-Beaupré plans to establish her own laboratory with independent research.
John Duda, MD
Associate Professor of Neurology at the Veteran's Administration Medical Center
Director, Parkinson’s Disease Research, Education & Clinical Center, Philadelphia Veterans Affairs Medical Center
John Duda is the Director of the Parkinson's Disease Research, Education and Clinical Center (PADRECC) of the Cpl. Michael J. Crescenz VA Medical Center and an Associate Professor of Neurology at the Perelman School of Medicine at the University of Pennsylvania. For the past 15 years, he has worked with his colleagues in Philadelphia to provide state-of-the-art care for thousands of Veterans with PD and related disorders. In collaboration with the other 5 PADRECCs in the VA system, they have advanced care for all Veterans by helping to develop national guidelines for care, and by developing the National VA PD Consortium, which serves as a model for providing access to expert-level care across the nation’s largest integrated healthcare network. His research activities have included basic science investigations into the role of Lewy pathology in the pathophysiology of Parkinson’s disease and related disorders as well as investigations into the mechanisms involved in the development of chronic traumatic encephalopathy. He has also conducted clinical research in Parkinson’s disease with studies of deep brain stimulation therapy, transcranial magnetic stimulation, the benefits of a plant-based, whole food diet, and the use of olfaction as a biomarker of disease diagnosis and progression. He has received research grants from the Department of Veterans Affairs, NIH, the Michael J. Fox Foundation for Parkinson Research, the Samueli Foundation and the Pennsylvania State Department of Health. He is a founding and current member of the Scientific Advisory Board for the Lewy Body Dementia Association. He has served on the Editorial Boards of Movement Disorders and npj Parkinson’s Disease and has been a peer reviewer for over 30 journals. He has authored more than 100 scientific publications including articles in JAMA, Science, Neuron, The New England Journal of Medicine and Neurology.
Book Author; Person with Young Onset Parkinson’s Disease;
Expert On Writing About Parkinson’s For Children To Better Understand This Disease
Diagnosed with Parkinson's disease at the age of 38, Adele Hensley is the author of a new book of poetry, and three books written for children about different aspects of Parkinson's disease. The children's books are Monica, Mama, and the Ocotillo's Leaves, about the process of diagnosis, How Marty's Mom Became A Cyborg, about Deep Brain Stimulation (DBS) therapy, and Face It: Making Peace With Fear, about the anxiety associated with Parkinson's. The new book of poetry is just out in September 2016 and is called Twelve Years and Counting. It is about living with Parkinson's disease and the feelings that it causes. Adele Hensley lives in Clinton, Mississippi, with her husband Frank who is a biology professor, her sixteen year-old son Clark, and their Labrador retriever, Gryff.
PhD Candidate, Cullen Lab, Neuroscience Graduate Group, University of Pennsylvania
Carolyn Keating (USA) is a graduate student at the University of Pennsylvania in Philadelphia, PA and works in the laboratory of Dr. D. Kacy Cullen, where she is studying the connection between traumatic brain injury (TBI) and chronic neurodegeneration. More specifically, she is examining the relationship between repetitive TBI and the aggregation and cell-to-cell transmission of proteins such as alpha-synuclein. Prior to joining the Neuroscience Graduate Group at Penn, Keating received her Bachelor of Arts in Neuroscience from Colgate University and spent two years at the National Institutes of Health as a post baccalaureate fellow.
Dance for PD®
David Leventhal is a former dancer with the Mark Morris Dance Group (MMDG). Leventhal is currently the program director and one of the founding teachers of MMDG’s Dance for PD® (Parkinson's Disease) program, which was originally conceived by Olie Westheimer. Begun in 2001 as a small monthly class for the Brooklyn Parkinson Group, the program has expanded to include weekly classes throughout New York City, training workshops for teachers in cities around the US and abroad, and a network of affiliated classes in more than 100 cities in 16 countries around the world. With a vision for increasing access to the joys and benefits of dance, he’s co-produced three volumes of a successful At Home DVD series for the program and has been instrumental in initiating and designing innovative projects involving live streaming and Moving Through Glass, a dance-based Google Glass App for people with Parkinson’s. Along with Westheimer, he is the co-recipient of the 2013 Alan Bonander Humanitarian Award from the Parkinson's Unity Walk. He has written about dance and Parkinson's for such publications as Dance Gazette and Room 217, and has a chapters about the program in two books: Multimodal Learning in Communities and Schools (Peter Lang) and Creating Dance: A Traveler's Guide (Hampton Press). He’s a passionate ambassador and spokesperson for the value of dance for people with Parkinson’s at such forums as the Lincoln Center Global Exchange and the Edinburgh International Culture Summit.
Ignacio F. Mata, PhD
Research Biologist, Veterans Affairs Puget Sound Health Care System, Seattle, Wash.; Acting Assistant Professor of Neurology at the University of Washington, Seattle, Wash.
Ignacio F. Mata, PhD is a Research Biologist at the Veterans Affairs Puget Sound Health Care System (Seattle, WA) and an Acting Assistant Professor of Neurology at the University of Washington (Seattle, WA). He has been working in the field of Parkinson's disease (PD) genetics for nearly 15 years. He is a co-investigator on Project 1 of the Pacific Northwest Udall Center (PANUC) seeking to identify genetic risk factors for cognitive impairment in PD. He has recently showed how APOE-ɛ4 APOE-ɛ4 was primarily associated with lower performance on semantic verbal fluency (animals) and word-list learning (40), similar to the cognitive profile in early AD, in comparison to variants in GBA which are associated with impairment in working memory/executive function and visuospatial abilities. He is also co-director of the Latin American Research Consortium on the Genetics of Parkinson’s Disease (LARGE-PD), a rapidly expanding collaboration among six institutions in five countries across South America aimed at generating a unique resource to study the genetics of PD in admixed and Latino populations. Just recently, he was awarded one of the first 3 Stanley Fahn Junior Faculty Awards by the Parkinson’s Disease Foundation to use the LARGE-PD cohort to perform the first large-scale genetic study in Latinos with PD to date. He is also involved in the Parkinson’s Genetic Research Study (PaGeR) helping analyze multi-generational PD families using Next Generation Sequencing, to identify novel PD genes. He has authored more than 55 peer-reviewed articles and often reviews for over 10 journals.
Matthew A. Sacheli, MSc., CSEP-CEP
Matthew Sacheli is a PhD Candidate at the University of British Columbia (UBC) in Vancouver, BC, Canada. He is under the supervision of Dr. A Jon Stoessl at the Pacific Parkinson’s Research Center (PPRC) and the Djavad Mowafaghian Centre for Brain Health. Prior to UBC, Matt completed a BSc. (Hons) at the University of Ottawa, obtained his certification in exercise physiology (CSEP-CEP) and completed his MSc. at Wilfrid Laurier University. The focus of Matt’s research is investigating the therapeutic mechanisms of exercise in Parkinson’s disease using PET and fMRI neuroimaging.
S. Pablo Sardi, PharmD, PhD
Richard Jay Smeyne, PhD
Professor, Department of Neuroscience
Director, Jefferson Comprehensive Parkinson’s Center
Vickie & Jack Farber Institute for Neuroscience
Thomas Jefferson University
Richard Smeyne, Ph.D. currently holds the title of Professor in the Department of Neurosciences and Director of the Jefferson Comprehensive Parkinson’s Center at Thomas Jefferson University. Dr. Smeyne’s multidisciplinary research program focuses on the cell biology of Parkinson’s disease.
Smeyne earned his Bachelors of Science degree in Biology from St. Joseph’s University and his Ph.D. in Anatomy from Thomas Jefferson University (both in Philadelphia). Following his Ph.D., Smeyne did postdoctoral research at the Roche Institute of Molecular Biology in Nutley, NJ, where he studied with Jim Morgan and Tom Curran and generated the first transgenic mouse carrying an inducible gene (fos-lacZ). Following his postdoctoral work, he started his own lab at the Bristol Myers Squibb Pharmaceutical Research Center where he became recognized for his analysis of mice carrying mutations of the neurotrophin receptors TrkA, TrkB and TrkC. Smeyne was subsequently recruited to become the Head of the Neurogenetics Program in the Department of CNS Research at Hoffmann-LaRoche, where he lead a program examining the molecular and cellular mechanisms underlying neurodegeneration as well as those in obesity signaling. In 1996, Smeyne was recruited as a founding member of the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital in Memphis TN.
At St. Jude and now at Thomas Jefferson, Smeyne is continuing his long-standing interest in the cell biology of Parkinson’s disease, examining both environmental and genetic models of the disease. Smeyne’s lab is recognized for several major breakthroughs in Parkinson’s disease. His lab was one of the first to experimentally demonstrate that exercise can be neuroprotective in models of Parkinson’s disease, which has led to the use of exercise as standard therapy in the treatment of Parkinson’s disease. Recently, Smeyne has identified an early molecular switch that underlies the neuroprotective influences of exercise.
In addition, Smeyne’s lab has become a leader in the field of neuroimmunology, where he has shown that viruses can be a predisposing factor in the etiology of Parkinson’s disease. Smeyne’s lab also examines mouse models of Parkinson's disease that result from known genetic mutations. In particular, the lab has been examining mice that carry mutations in the alpha-synuclein or LRRK2 genes to inquire how alterations in these genes may interact with other environmental stressors as modifiers of disease complexity.
Morten Gersel Stokholm, MD
Researcher, Department of Clinical Medicine, Aarhus University and the Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital, Denmark
Morten Gersel Stokholm, MD has obtained his medical degree at Aarhus University, Denmark. During his medical studies he has worked at the Department of Neurology, Vejle Hospital, Denmark and he has been actively involved in research projects at the Department of Nuclear Medicine & PET-Centre and the Institute of Pathology, Aarhus University Hospital. Since February 2015 he has been employed as a PhD student at the Department of Clinical Medicine, Aarhus University and he carries out his clinical research at the Department of Nuclear Medicine & PET-Centre, Aarhus University Hospital. His PhD project is funded by a grant from the Danish Council for Independent Research which was given to his main supervisor Professor Nicola Pavese. Additionally, he was awarded a personal grant by the Aarhus University Research Foundation for the whole duration of his PhD.
The project is an international collaboration between researchers at Aarhus University and Hospital Clínic de Barcelona. By the use of Positron Emission Tomography (PET) scans they investigate the presence of neuroinflammation and changes in neurotransmitter systems in the brain of patients with idiopathic rapid-eye-movement sleep behaviour disorder, a condition that is now considered a prodromal state of neurodegenerative diseases such as Parkinson disease, dementia with Lewy bodies or multiple system atrophy. The main aim of the research is to elucidate pathological mechanisms involved in the early phases of development of these disorders and to identify possible therapeutic targets.